Beilstein J. Org. Chem.2017,13, 303–312, doi:10.3762/bjoc.13.33
Systems Biology, VIB, Ghent University, Technologiepark 927, B-9000 Ghent, Belgium Department of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium 10.3762/bjoc.13.33 Abstract For the synthesis of m-sulfamoylbenzamideanalogues, small molecules which are
, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamideanalogues.
Keywords: flow chemistry; medium-throughput synthesis; m-sulfamoylbenzamideanalogues; Introduction
Small
be effective against Huntington’s and Parkinson’s disease [12][13][14]. They inhibit the Sirtuin 2 (SIRT2) deacetlyse protein (Figure 1, AK-1, AK-7) resulting in improved motor skills [12][13][15]. Furthermore, m-sulfamoylbenzamideanalogues (Figure 1, C2-8) are able to suppress polyglutamine (polyQ
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Graphical Abstract
Figure 1: m-Sulfamoylbenzamides as Sirtuin 2 inhibitors (SIRT2) or suppressor of polyglutamine aggregation (p...